The r2_loader64.dll file is a 64-bit runtime component required by certain Ubisoft titles. Its primary functions include:

The Uplay R2 Loader64.dll error is a common issue that occurs when the game's loader fails to initialize the Uplay R2 library. Uplay is a digital distribution platform developed by Ubisoft, and the R2 Loader64.dll is a crucial component of the Uplay client. When the loader fails to load the R2 Loader64.dll, the game crashes, and an error message appears.

If you are using a modded version, antiviruses frequently target loader files. Open your antivirus software (e.g., Windows Defender). Go to or Quarantine . Look for r2_loader64.dll . If found, select it and choose Restore or Allow .