This means your translation patch is designed for a specific revision of the game, and your Japanese ISO does not match it. Ensure your base ISO is a clean, unedited dump of the retail Japanese release.
A: Not without a mod. The game is NTSC-J region locked. You would need a Japanese console, a modchip, or a swap disc method to bypass the region lock. It is much easier to play on PCSX2.
Step-by-step (emulator)