In an individual with active or latent lupus, the immune system is hyper-reactive. Mechanical stress can cause localized cellular damage, releasing intracellular antigens. The body’s autoantibodies recognize these fragments as foreign, initiating a localized inflammatory cascade.
A rare form of the condition called affects the deepest layers of subcutaneous fat. LEP lesions often present as painful, deep-seated nodules on areas prone to pressure or impact, including the upper arms, thighs, and buttocks. Physical trauma to these areas can aggravate these deep-tissue lumps, leading to localized pain and long-term skin dimpling.
