Another approach involves breaking on GetVersion or searching for patterns like sub esp, 0x58 that are characteristic of compiler-generated startup code. For executables compiled with Microsoft Visual Studio, OEPs often begin with a call to ___security_init_cookie , which can serve as a locating heuristic.
Themida 3.x employs an aggressive, multi-layered defensive strategy designed to detect and neutralize analysis environments: Themida 3.x Unpacker
( -mode b ): Compares RIP against all mapped DLL memory to check functions, emulating blocks of code (calls, jumps). emulating blocks of code (calls